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Seema Lakdawala, PhD








				

		Dr. Seema Lakdawala	
		

		    	
        
Contact
        
	
					

			lakdawala@pitt.edu	
			

		
					

			412-383-6406	
			

			
        		

		Fax: 412-624-2139	
		

		
		
					
421 Bridgeside Point 2
450 Technology Drive
		
        
                
        







	

	
Education
PhD in Biological Sciences, University of California
BSc in Natural Sciences, University of Texas
	



    




	

		
Academic Affiliation(s)

	
Assistant Professor, Department of Microbiology and Molecular Genetics
Member, Molecular Virology and Microbiology
	
	







Research
Influenza A viruses pose a major public health risk from seasonal epidemics and sporadic pandemics. My lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses.
Lab Personnel
Amar Bhagwat (Research Assistant Professor)
Eric Nturibi (Technician)
Valerie Le Sage (Research Associate)
Karen Kormuth (Postdoctoral Fellow)
Areas of Interest
Virology, Emerging influenza viruses, Virus Assembly, Virus Transmission, Microscopy, Live Cell Imaging



















Publications
	

	
Lakdawala S.S, Jayaraman A, Halpin R.A, Lamirande E.W, Shih A.R, Stockwell T.B, Lin X, Simenauer A, Hanson C.T, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das S.R, Wentworth D.E, Sasisekharan R. and Subbarao K. The soft palate is an important site of adaptation for transmissible influenza viruses. Nature. 526: 122-125. |  View Abstract
Lakdawala S.S, Wu Y, Wawrzusin P, Kabat J, Broadbent A.J, Lamirande E.W, Fodor E, Altan-Bonnet N, Shroff H. and Subbarao K. Influenza a virus assembly intermediates fuse in the cytoplasm. PLoS Pathog. 10: e1003971. |  View Abstract
Lakdawala S.S, Shih A.R, Jayaraman A, Lamirande E.W, Moore I, Paskel M, Sasisekharan R. and Subbaro K. Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets. Virology. 446: 349-356. |  View Abstract
Lakdawala, S.S. and Subbarao K. The ongoing battle against influenza: The challenge of flu transmission. Nat Med. 18: 1468-1470. |  View Abstract
Lakdawala S.S, Lamirande E.W, Suguitan A.L., Jr., Wang W, Santos C.P, Vogel L, Matsuoka Y, Lindsley W.G, Jin H and Subbarao K. Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus. PLoS Pathog. 7: e1002443. |  View Abstract
Luke C, Lakdawala S.S. and Subbarao K. "Chapter 16: Influenza Vaccine-Live." VACCINES, Sixth Ed., Elsevier.