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Patrick S. Moore, MD, MPH

Dr. Pat Moore


1.9 Hillman Cancer Center
5117 Center Avenue


MPH, University of California, Berkeley

MD and MPhil, University of Utah

MS, Stanford University

BS, Westminster College

Academic Affiliation(s)

Distinguished and American Cancer Society Professor, Department of Microbiology and Molecular Genetics
Director, UPCI Cancer Virology Program


Our work involves understanding how two different human cancer viruses we discovered (KSHV and MCV) initiate tumors.  We also seek to identify other undiscovered human cancer viruses.

Lab Personnel

Lab Co-director: Professor Yuan Chang, Pathology

Areas of Interest

Tumor virology, cap-dependent translation, virus targeting of human tumor suppressor pathways


Velasquez C, Cheng E, Shuda M, Lee-Oesterreich P.J, Pogge von Strandmann L, Gritsenko M.A, Jacobs J.M, Moore P.S. and Chang Y. Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci USA. 113: 8644-8471. |  View Abstract

Toptan T, Yousem S.A, Ho J, Matsushima Y, Stabile L.P, Fernandez-Figueras M.T, Bhargava R, Ryo A, Moore P.S. and Chang Y. Survey for human polyomaviruses in cancer. JCI Insight. 1: e85562. |  View Abstract

Shuda M, Velasquez C, Cheng E, Cordek D.G, Kwun H.J, Chang Y. and Moore P.S. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci USA. 112: 5875-5882. |  View Abstract

Wendzicki J.A, Moore P.S. and Chang Y. Large T and small T antigens of Merkel cell polyomavirus. Curr Opin Virol. 11: 38-43. |  View Abstract

Kwun H.J, Shuda M, Camacho C.J, Gamper A.M, Thant M, Chang Y. and Moore P.S. Restricted protein phosphatase 2A targeting by Merkel cell polyomavirus small T antigen. J Virol. 89: 4191-4200. |  View Abstract

Chang Y. and Moore P.S. Twenty years of KSHV. Viruses. 6: 4258-4264. |  View Abstract

Li Z, Ender C, Meister G, Moore P. S, Chang Y, and John B. Extensive terminal and asymmetric processing of small RNAs from rRNAs, snoRNAs, snRNAs, and tRNAs. Nucleic Acids Res. 40: 6787-6799. |  View Abstract