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Ora A. Weisz, PhD








				

		Dr. Ora Weisz	
		

		    	
        
Contact
        
	
					

			weisz@pitt.edu	
			

		
					

			412-383-8891	
			

			
        		

		Fax: 412-383-8956	
		

		
		
					
978.1 Scaife Hall
3550 Terrace Street
		
        
                
        







	

	
Education
PhD, John Hopkins Medical School
BS, Yale University
	



    




	

		
Academic Affiliation(s)

	
Professor, Department of Medicine, Renal-Electrolyte Division
Professor, Department of Cell Biology
Vice-chair of Faculty Development, Department of Medicine
Assistant Dean for Faculty Development, School of Medicine
	
	







Research
The focus of our laboratory is the regulation of apical membrane traffic in polarized epithelial cells. We are interested in unraveling the mechanisms by which proteins are selected for apical delivery, incorporated into vesicular carriers, and targeted to the appropriate membrane. Various projects in the laboratory address different aspects of this highly complex process.
Lab Personnel:
Jennifer Bruns, Research Specialist
Simone Costa, Research Specialist
Anatalia Labilloy, Graduate Student
Polly Mattila, Instructor
Venky Raghavan, Graduate Student
Youssef Rbaibi, Research Specialist
Christina Szalinski, Graduate Student
Robert Youker, Instructor



















Publications
	

	
Rbaibi Y, Cui S, Mo D, Carattino M, Rohatgi R, Satlin L. M, Szalinski C. M, Swanhart L. M, Folsch H, Hukriede N. A, and Weisz O. A. OCRL1 Modulates Cilia Length in Renal Epithelial Cells. Traffic. 13: 1295-1305. |  View Abstract
Mo D, Ihrke G, Costa S. A, Brilli L, Labilloy A, Halfter W, Cosentino C. C, Hukriede N. A, and Weisz O. A. Apical Targeting and Endocytosis of the Sialomucin Endolyn are Essential for Establishment of Zebrafish Pronephric Kidney Function. J Cell Sci. [Epub ahead of print] |  View Abstract
Mo D, Costa S. A, Ihrke G, Youker R. T, Pastor-Soler N, Hughey R. P, and Weisz O. A. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9 dependent mechanism. Mol Biol Cell. 18: 3636-3646. |  View Abstract
Cui S, Guerriero C. J, Szalinski C. M, Kinlough C. L, Hughey R. P, and Weisz O. A. OCRL1 function in renal epithelial membrane traffic. Am J Physiol Renal Physiol. 298: F335-F345. |  View Abstract
Miedel M. T, Rbaibi Y, Guerriero C. J, Colletti G, Weixel K. M, Weisz O. A, and Kiselyov K. Membrane traffic and turnover in TRP-ML1-deficient cells: a revised model for mucolipidosis type IV pathogenesis. J Exp Med. 205: 1477-1490. |  View Abstract
Khandelwal P, Ruiz W. G, Balestreire-Hawryluk E, Weisz O. A, Goldenring J. R, and Apodaca G. Rab11a-dependent exocytosis of discoidal/fusiform vesicles in bladder umbrella cells. Proc Natl Acad Sci USA. 105: 15773-15778. |  View Abstract
Cresawn K. O, Potter B. A, Oztan A, Guerriero C. J, Ihrke G, Goldenring J. R, Apodaca G, and Weisz O. A. Differential involvement of endocytic compartments in the biosynthetic traffic of apical proteins. Embo J. 26: 3737-3748. |  View Abstract